Which side effects are reported most for lisinopril?

Fatigue (20,512 reports), nausea and diarrhea are the reactions named most often in the roughly 314,000 reports to the FDA, as of June 2026, that list lisinopril (Zestril, Prinivil) among a patient's medicines. Kidney injury, which its label warns about, has about 9,700. People taking it for blood pressure often take other medicines too, so common complaints lead the list for most drugs. A report is not proof the medicine caused the problem: anyone can send one, it lists every medicine the person was taking, and the same case can be reported twice. Reports that the medicine didn't work or was used differently than labeled are left out. Don't stop a medicine without talking to a doctor.

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Key facts

Measure: Reports to the FDA naming lisinopril. Written from the data below.

  • Fatigue has the highest figure, 20,512, followed by Nausea (19,128) and Diarrhea (17,857).
  • Rash has the lowest figure, 8,799, followed by High blood pressure (9,000) and Chronic kidney disease (9,197).
  • The highest is 2.3 times the lowest.

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Chartly. “Which side effects are reported most for lisinopril?” Chart. Data: U.S. Food and Drug Administration, Adverse Event Reporting System (FAERS) via openFDA, https://open.fda.gov/apis/drug/event/ (data as of June 30, 2026). https://chart.ly/charts/lisinopril-side-effects-reported (accessed October 15, 2026).

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Reported reaction Reports to the FDA naming lisinopril
Fatigue 20,512
Nausea 19,128
Diarrhea 17,857
Shortness of breath 14,364
Pain 14,064
Dizziness 13,972
Headache 13,420
Vomiting 11,371
Weakness 11,283
Joint pain 9,943
Acute kidney injury 9,725
Falls 9,408
Chronic kidney disease 9,197
High blood pressure 9,000
Rash 8,799

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