Which side effects are reported most for lisinopril?

Fatigue (20,635 reports), nausea and diarrhea are the reactions named most often in reports to the FDA, as of September 2026, that list lisinopril (Zestril, Prinivil) among a patient's medicines. Its label warns about kidney injury. People taking it for blood pressure often take other medicines too, so common complaints lead the list for most drugs. A report is not proof the medicine caused the problem: anyone can send one, it lists every medicine the person was taking, and the same case can be reported twice. Reports that the medicine didn't work or was used differently than labeled are left out. Don't stop a medicine without talking to a doctor.

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Key facts

Measure: Reports to the FDA naming lisinopril. Written from the data below.

  • Fatigue has the highest figure, 20,635, followed by Nausea (19,219) and Diarrhea (17,984).
  • Rash has the lowest figure, 8,891, followed by High blood pressure (9,001) and Chronic kidney disease (9,181).
  • The highest is 2.3 times the lowest.

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Source and date

Source
U.S. Food and Drug Administration, Adverse Event Reporting System (FAERS) via openFDA
License
Public domain (U.S. government work); source U.S. Food and Drug Administration, openFDA
Data as of
Published

Citation

Chartly. “Which side effects are reported most for lisinopril?” Chart. Data: U.S. Food and Drug Administration, Adverse Event Reporting System (FAERS) via openFDA, https://open.fda.gov/apis/drug/event/ (data as of September 30, 2026). https://chart.ly/charts/lisinopril-side-effects-reported (accessed November 5, 2026).

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The data

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The file has the numbers in this table, with the source, license and date. Please credit the source and Chartly. Developers can also get them as JSON (how).

Reported reaction Reports to the FDA naming lisinopril
Fatigue 20,635
Nausea 19,219
Diarrhea 17,984
Shortness of breath 14,412
Pain 14,134
Dizziness 14,083
Headache 13,511
Vomiting 11,457
Weakness 11,308
Joint pain 10,026
Acute kidney injury 9,743
Falls 9,428
Chronic kidney disease 9,181
High blood pressure 9,001
Rash 8,891

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