What do Americans aged 85 and over die of most often?

In the 12 months through June 2025, heart disease was the leading cause of death for Americans aged 85 and over, at 3,759 deaths per 100,000 people that age, more than twice the rate for cancer (1,631). Stroke (1,064) and Alzheimer disease (1,039) came next. The numbers are provisional.

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Key facts

Measure: Deaths per 100,000 people aged 85 and over in a year. Written from the data below.

  • Heart disease has the highest figure, 3,759.1, followed by Cancer (1,630.7) and Stroke (1,064.4).
  • Hypertension has the lowest figure, 247.9, followed by Kidney disease (257.2) and Diabetes (271.4).
  • The highest is 15 times the lowest.

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Citation

Chartly. “What do Americans aged 85 and over die of most often?” Chart. Data: CDC National Center for Health Statistics, Quarterly provisional estimates of mortality, https://www.cdc.gov/nchs/nvss/vsrr/mortality-dashboard.htm (data as of June 30, 2025). https://chart.ly/charts/causes-of-death-ages-85-and-over (accessed October 15, 2026).

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Cause of death Deaths per 100,000 people aged 85 and over in a year
Heart disease 3,759.1
Cancer 1,630.7
Stroke 1,064.4
Alzheimer disease 1,039.2
Chronic lower respiratory diseases 567.8
Unintentional injuries 428.1
Influenza and pneumonia 285.1
Diabetes 271.4
Kidney disease 257.2
Hypertension 247.9

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